Why are hematopoietic stem cells so ‘sexy’? on a search for developmental explanation

@article{Ratajczak2017WhyAH,
  title={Why are hematopoietic stem cells so ‘sexy’? on a search for developmental explanation},
  author={Mariusz Z Ratajczak},
  journal={Leukemia},
  year={2017},
  volume={31},
  pages={1671-1677}
}
Evidence has accumulated that normal human and murine hematopoietic stem cells express several functional pituitary and gonadal sex hormones, and that, in fact, some sex hormones, such as androgens, have been employed for many years to stimulate hematopoiesis in patients with bone marrow aplasia. Interestingly, sex hormone receptors are also expressed by leukemic cell lines and blasts. In this review, I will discuss the emerging question of why hematopoietic cells express these receptors. A… CONTINUE READING
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