Why are hematopoietic stem cells so ‘sexy’? on a search for developmental explanation

  title={Why are hematopoietic stem cells so ‘sexy’? on a search for developmental explanation},
  author={Mariusz Z Ratajczak},
Evidence has accumulated that normal human and murine hematopoietic stem cells express several functional pituitary and gonadal sex hormones, and that, in fact, some sex hormones, such as androgens, have been employed for many years to stimulate hematopoiesis in patients with bone marrow aplasia. Interestingly, sex hormone receptors are also expressed by leukemic cell lines and blasts. In this review, I will discuss the emerging question of why hematopoietic cells express these receptors. A… CONTINUE READING
Highly Cited
This paper has 322 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-9 of 9 extracted citations

323 Citations

Citations per Year
Semantic Scholar estimates that this publication has 323 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 102 references

Adult murine bone marrowderived very small embryoniclike stem cells Sex hormones and hematopoietic stem cells

  • E Zuba-Surma, W Wan, M Kucia, MC Yoder
  • 2017

Phase I/II trial of stemregenin-1 expanded umbilical cord blood hematopoietic stem cells supports testing as a stand-alone graft

  • JE JrWagner, CG Brunstein, AE Boitano, TE DeFor, D McKenna, D Sumstad
  • Cell Stem Cell 2016;
  • 2016

Similar Papers

Loading similar papers…