Why are both ends of the polypeptide chain on the outside of proteins?

@article{Hovmller2004WhyAB,
  title={Why are both ends of the polypeptide chain on the outside of proteins?},
  author={Sven Hovm{\"o}ller and Tuping Zhou},
  journal={Proteins: Structure},
  year={2004},
  volume={55}
}
Protein folding starts before the whole polypeptide has been synthesized by the ribosome. No matter how long the polypeptide is or how intricate the fold, both ends of the chain always end up on the surface. From a topological point of view, this is surprising; one would have expected to find the starting (N‐terminal) end inside the core of the folded protein, just as in a ball of yarn. We suggest here that the reason for this apparent paradox is that the first amino acid of the emerging… 
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