Why are RNA virus mutation rates so damn high?
@article{Duffy2018WhyAR, title={Why are RNA virus mutation rates so damn high?}, author={Siobain Duffy}, journal={PLoS Biology}, year={2018}, volume={16} }
The high mutation rate of RNA viruses is credited with their evolvability and virulence. This Primer, however, discusses recent evidence that this is, in part, a byproduct of selection for faster genomic replication.
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References
SHOWING 1-10 OF 29 REFERENCES
The cost of replication fidelity in an RNA virus.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2005
It is demonstrated that the observed mutation rate in vesicular stomatitis virus can be explained by a trade-off between replication rate and replication fidelity.
Does Mutation Rate Depend on Itself?
- BiologyPLoS biology
- 2008
Recent evidence suggests that mutation rates are fitness-dependent, broadening our view of the impacts of mutation on the genetic health of populations.
A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus
- BiologyPLoS biology
- 2018
The data are consistent with the kinetic proofreading model for biosynthetic reactions and suggest that speed is more important than accuracy in RNA viruses, and it is found that within-host spread is associated with viral replicative speed and not standing genetic diversity.
Extremely High Mutation Rate of a Hammerhead Viroid
- BiologyScience
- 2009
The results suggest that the emergence of replication fidelity was critical for the evolution of complexity in the early history of life, and the highest mutation rate reported for any biological entity is suggested.
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population
- BiologyNature
- 2006
Analysis of viruses isolated from brain provides direct evidence for complementation between members in the quasispecies, indicating that selection indeed occurs at the population level rather than on individual variants.
Adaptive Value of High Mutation Rates of RNA Viruses: Separating Causes from Consequences
- BiologyJournal of Virology
- 2005
The argument that the more mutations are generated, the faster adaptation proceeds is flawed because it ignores the fact that the vast majority of mutations are deleterious, hence hindering adaptation, as shown by recent theoretical developments.
Cell Tropism Predicts Long-term Nucleotide Substitution Rates of Mammalian RNA Viruses
- BiologyPLoS pathogens
- 2014
Estimated viral generation times suggest that epithelial-infecting viruses replicate more quickly than viruses with different cell tropisms, indicating that cell tropism is a key factor in viral evolvability.
Coronaviruses as DNA Wannabes: A New Model for the Regulation of RNA Virus Replication Fidelity
- BiologyPLoS pathogens
- 2013
The stability of the ExoN− genotype and phenotype provides a powerful model for the study of additional CoV fidelity determinants and of the effects of altered fidelity on virus replication, fitness, host-species range, and response to environmental changes.