Why anti-Bcl-2 clinical trials fail: a solution

  title={Why anti-Bcl-2 clinical trials fail: a solution},
  author={Yosuke Harazono and Kosei Nakajima and Avraham Raz},
  journal={Cancer and Metastasis Reviews},
The alteration in expression of B cell lymphoma-2 (Bcl-2) family of protein members in cancer is involved mainly in the regulation of apoptosis. Bcl-2 family proteins are currently used as major targets in the development of methods to improve treatment outcomes for cancer patients that underwent clinical trials. Although many agents have been developed for targeting Bcl-2 in the past decade, some previous attempts to target Bcl-2 have not resulted in beneficial clinical outcome for reasons… CONTINUE READING
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