Corpus ID: 33564858

Why TestoBoost is Better than the Prohormones or Replacement therapy with Testosterone or Anabolic Steroids

  title={Why TestoBoost is Better than the Prohormones or Replacement therapy with Testosterone or Anabolic Steroids},
  • Published 2013
This study tested the hypothesis that nitric oxide (NO) inhibits the rate-limiting catalytic step in steroidogenesis, cytochrome P450 cholesterol side-chain cleaving enzyme (CYP11A1), independent of soluble guanylyl cyclase (GC-S) stimulation. To assess CYP11A1 activity, pregnenolone levels were quantified in murine adrenocortical Y1 cells in the presence of the 3beta-hydroxy-Delta(5)-steroid dehydrogenase inhibitor, 2alpha-cyano-17beta-hydroxy4,4',17alpha-trimethylandrost-5-ene-3-one. The NO… Expand


Binding characteristics of aromatase inhibitors and phytoestrogens to human aromatase
The investigation reveals that phytoestrogens bind to the active site of aromatase in a different orientation from that in the estrogen receptor. Expand
5α-Reductase-catalyzed conversion of testosterone to dihydrotestosterone is increased in prostatic adenocarcinoma cells: suppression by 15-lipoxygenase metabolites of gamma-linolenic and eicosapentaenoic acids
  • H. Pham, V. Ziboh
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 2002
The study underscores the biological importance of 15-lipoxygenase metabolites of polyunsaturated fatty acids (PUFAs) in androgen metabolism and demonstrates that nutrients derived from dietary sources can exert similar therapeutic promise. Expand
Indole-3-carbinol is a negative regulator of estrogen.
A synergistic effect of I3C and genistein is shown for induction of GADD expression, thus increasing apoptosis, and for decrease of expression driven by ER-alpha. Expand
Involvement of D-aspartic acid in the synthesis of testosterone in rat testes.
The results suggest that free D-Asp is involved in the steroidogenesis, and it is demonstrated that this amino acid induces the synthesis of testosterone. Expand
A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.
This study establishes the effectiveness of naturally occurring 5AR inhibitors against AGA for the first time, and justifies the expansion to larger trials. Expand
The effect of L-acetylcarnitine on some reproductive functions in the oligoasthenospermic rat.
  • S. Palmero, M. Leone, +4 authors L. De Cecco
  • Biology, Medicine
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 1990
Both lactate dehydrogenase and NADPH-cytochrome P 450-reductase increased significantly after treatment with LAC in normal rats, suggesting that LAC may affect testicular function. Expand
Effect of alpha-ketoglutarate infusions on organ balances of glutamine and glutamate in anaesthetized dogs in the catabolic state.
Investigation of whether infusion of alpha-ketoglutarate affects the flux of glutamine and glutamate between skeletal muscle and the splanchnic bed in anaesthetized post-operative dogs found it did not alter the muscular glutamate or glutamine contents. Expand
The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats
D-aspartic acid is a physiological amino acid occurring principally in the pituitary gland and testes and has a role in the regulation of the release and synthesis of LH and testosterone in humans and rats. Expand
The effect of an α-ketoglutarate-pyridoxine complex on human maximal aerobic and anaerobic performance
It is concluded that α-KG complex stimulates aerobic metabolism, probably prompting mitochondrial reabsorption of α- KG, which activates the malate-oxalacetate shuttle and the generation of high energy phosphates at the substrate level. Expand
Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men.
AAKG supplementation appeared to be safe and well tolerated, and positively influenced 1RM bench press and Wingate peak power performance and did not influence body composition or aerobic capacity. Expand