Why T cells of thymic versus extrathymic origin are functionally different.

@article{Blais2008WhyTC,
  title={Why T cells of thymic versus extrathymic origin are functionally different.},
  author={Marie-{\`E}ve Blais and Sylvie Brochu and Martin Giroux and Marie-Pier B{\'e}langer and Gabriel Dulude and Rafick Pierre S{\'e}kaly and Claude Perreault},
  journal={Journal of immunology},
  year={2008},
  volume={180 4},
  pages={
          2299-312
        }
}
Age-related thymic involution severely impairs immune responsiveness. Strategies to generate T cells extrathymically are therefore being explored with intense interest. We have demonstrated that T cells produced extrathymically were functionally deficient relative to thymus-derived T cells. The main limitation of extrathymic T cells is their undue susceptibility to apoptosis; they thus do not expand properly when confronted with pathogens. Using oncostatin M-transgenic mice, we found that in… CONTINUE READING
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