Why Is Initial Bacterial Colonization of the Intestine Important to Infants' and Children's Health?

@article{Houghteling2015WhyII,
  title={Why Is Initial Bacterial Colonization of the Intestine Important to Infants' and Children's Health?},
  author={Pearl D Houghteling and W. Walker},
  journal={Journal of Pediatric Gastroenterology and Nutrition},
  year={2015},
  volume={60},
  pages={294–307}
}
ABSTRACT Microbial colonization of the infant occurs during a critical time window for immune and gastrointestinal development. Infant colonization sets the stage for the adult microbiome. This review is a broad survey of the factors affecting infant colonization and the downstream effects on gastrointestinal health and disease. Major topics affecting colonization include initial inoculation dependent on birth mode, the impact of breast-feeding, and inside-out modulation of the developing… 
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References

SHOWING 1-10 OF 156 REFERENCES
Microbial contact during pregnancy, intestinal colonization and human disease
TLDR
The current body of knowledge regarding perinatal microbial contact, initial intestinal colonization and its association with human disease, as well as means of modulating early host–microbe interaction to reduce the risk of disease in the child are described.
Developmental microbial ecology of the neonatal gastrointestinal tract.
TLDR
In this review, the development of the intestinal microbiota is discussed in terms of initial acquisition and subsequent succession of bacteria in human infants and the advantages of modern molecular ecology techniques that provide sensitive and specific, culture-independent evaluation of the gastrointestinal ecosystem are introduced.
Bacterial colonization of the neonatal gut.
  • M. Pietzak
  • Medicine, Biology
    Journal of pediatric gastroenterology and nutrition
  • 2004
TLDR
In this issue of JPGN, Bailey et al. propose that bacterial colonization of the gut might be impacted by stress in the pregnant mother, and suggest that the stress produced by the disruption of the maternal-infant bond may increase vulnerability to disease.
The Human Microbiome and Its Potential Importance to Pediatrics
TLDR
The aim of this review is to provide a detailed summary of current pediatric microbiome studies in the literature, in addition to highlighting recent findings and advancements in studies of the adult microbiome.
Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
TLDR
It is found that in direct contrast to the highly differentiated communities of their mothers, neonates harbored bacterial communities that were undifferentiated across multiple body habitats, regardless of delivery mode.
Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses
Introduction Among sensitized infants, those with high, as compared with low levels, of salivary secretory IgA (SIgA) are less likely to develop allergic symptoms. Also, early colonization with
Immunologic Factors in Human Milk and Disease Prevention in the Preterm Infant
TLDR
The immunological significance and antiinflammatory effects of a selection of the bioactive molecules found in human milk and how they may differ under conditions of preterm birth are reviewed.
Patterns of Early Gut Colonization Shape Future Immune Responses of the Host
TLDR
A time window exists that enables the artificial colonization of GF mice by a single oral dose of caecal content, which may modify the future immune phenotype of the host, as delayed microbial colonization of the gut causes permanent changes in the immune system.
Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months
TLDR
The gut microbiota of healthy Canadian infants is characterized and the effects of delivery mode and infant diet as determinants of this essential microbial community in early life are described and advance the understanding of the gut microbiota in healthy infants.
...
...