Why Escherichia coli alpha-hemolysin induces calcium oscillations in mammalian cells--the pore is on its own.

@article{Koschinski2006WhyEC,
  title={Why Escherichia coli alpha-hemolysin induces calcium oscillations in mammalian cells--the pore is on its own.},
  author={Andreas Koschinski and Holger Repp and Baris Unver and Florian Dreyer and Dierk Brockmeier and Angela Valeva and Sucharit Bhakdi and Iwan Walev},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 7},
  pages={973-5}
}
Escherichia coli alpha-hemolysin (HlyA), archetype of a bacterial pore-forming toxin, has been reported to deregulate physiological Ca2+ channels, thus inducing periodic low-frequency Ca2+ oscillations that trigger transcriptional processes in mammalian cells. The present study was undertaken to delineate the mechanisms underlying the Ca2+ oscillations. Patch-clamp experiments were combined with single cell measurements of intracellular Ca2+ and with flowcytometric analyses. Application of HlyA… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Similar Papers

Loading similar papers…