Why Does PEG 400 Co-Encapsulation Improve NGF Stability and Release from PLGA Biodegradable Microspheres?

@article{Pean1999WhyDP,
  title={Why Does PEG 400 Co-Encapsulation Improve NGF Stability and Release from PLGA Biodegradable Microspheres?},
  author={J Pean and Franck Boury and Marie-Claire Venier-Julienne and Philippe Menei and Jacques-Emile Proust and J F Benoit},
  journal={Pharmaceutical Research},
  year={1999},
  volume={16},
  pages={1294-1299}
}
Purpose. The aim of this work was to understand the mechanism by which co-encapsulated PEG 400 improved the stability of NGF and allowed a continuous release from PLGA 37.5/25 microspheres. Methods. Microparticles were prepared according to the double emulsion method. PEG 400 was added with NGF in the internal aqueous phase (PEG/PLGA ratio 1/1 and 1.8/1). Its effect was investigated through interfacial tension studies. Protein stability was assessed by ELISA. Results. A novel application of PEG… CONTINUE READING

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