Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality

@article{Zotenko2008WhyDH,
  title={Why Do Hubs in the Yeast Protein Interaction Network Tend To Be Essential: Reexamining the Connection between the Network Topology and Essentiality},
  author={Elena Zotenko and Juli{\'a}n Mestre and Dianne P. O'Leary and Teresa M. Przytycka},
  journal={PLoS Computational Biology},
  year={2008},
  volume={4},
  pages={41 - 42}
}
The centrality-lethality rule, which notes that high-degree nodes in a protein interaction network tend to correspond to proteins that are essential, suggests that the topological prominence of a protein in a protein interaction network may be a good predictor of its biological importance. Even though the correlation between degree and essentiality was confirmed by many independent studies, the reason for this correlation remains illusive. Several hypotheses about putative connections between… CONTINUE READING
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