Why CD8+ T cells need diversity when growing up.

  title={Why CD8+ T cells need diversity when growing up.},
  author={Kristin A Hogquist and Yan Xing},
  volume={32 1},
A thymus-specific subunit of the proteasome, beta5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that beta5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells. 

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