Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature

@inproceedings{Pan2017WholeTR,
  title={Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature},
  author={Yuan Pan and Erin C. Bush and Joseph A. Toonen and Yu Ma and Anne C. Solga and Peter A Sims and David H Gutmann},
  booktitle={Oncotarget},
  year={2017}
}
The concept that solid tumors are maintained by a productive interplay between neoplastic and non-neoplastic elements has gained traction with the demonstration that stromal fibroblasts and immune system cells dictate cancer development and progression. While less studied, brain tumor (glioma) biology is likewise influenced by non-neoplastic immune system cells (macrophages and microglia) which interact with neoplastic glioma cells to create a unique physiological state (glioma ecosystem… CONTINUE READING
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