Whole-tract reduction in fractional anisotropy in the corticospinal tracts of amyotrophic lateral sclerosis patients , as measured using a weighted 3-D region of interest in template space after deformable diffusion tensor imaging registration

Introduction: Amyotrophic lateral sclerosis (ALS) is a degenerative disease of motor neurons. Diffusion tensor imaging (DTI) measurements in the corticospinal tract (CST) of patients with ALS have shown local reductions in fractional anisotropy (FA), thought to reflect degeneration of the upper motor neuron axons. Regions-of-interest (ROI) measurements can… CONTINUE READING