Whole-proteome genetic analysis of dependencies in assembly of a vertebrate kinetochore

Abstract

Kinetochores orchestrate mitotic chromosome segregation. Here, we use quantitative mass spectrometry of mitotic chromosomes isolated from a comprehensive set of chicken DT40 mutants to examine the dependencies of 93 confirmed and putative kinetochore proteins for stable association with chromosomes. Clustering and network analysis reveal both known and… (More)
DOI: 10.1083/jcb.201508072

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