Whole-mount pathologic analysis of rectal cancer following neoadjuvant therapy: implications of margin status on long-term oncologic outcome.

@article{Mezhir2012WholemountPA,
  title={Whole-mount pathologic analysis of rectal cancer following neoadjuvant therapy: implications of margin status on long-term oncologic outcome.},
  author={James J. Mezhir and Jinru Shia and Elyn R. Riedel and Larissa K. F. Temple and Garrett Nash and Martin R Weiser and Philip B. Paty and W. Douglas Wong and Jos{\'e} G. Guillem},
  journal={Annals of surgery},
  year={2012},
  volume={256 2},
  pages={
          274-9
        }
}
OBJECTIVE Extent of distal resection margins in rectal cancer surgery remains controversial. We set out to determine the long-term oncologic impact of resection margins in patients with locally advanced rectal cancer using a comprehensive pathologic whole-mount section analysis. BACKGROUND It has been demonstrated that there is minimal disease beyond the gross tumor margin after neoadjuvant combined modality therapy (CMT) for rectal cancer. Although this suggests that close resection margins… CONTINUE READING
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