Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform.

@article{Lee2012WholeLM,
  title={Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform.},
  author={Sung Sik Lee and Ima Avalos Vizcarra and Daphne H. E. W. Huberts and Luke P. Lee and Matthias Heinemann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 13},
  pages={
          4916-20
        }
}
Important insights into aging have been generated with the genetically tractable and short-lived budding yeast. However, it is still impossible today to continuously track cells by high-resolution microscopic imaging (e.g., fluorescent imaging) throughout their entire lifespan. Instead, the field still needs to rely on a 50-y-old laborious and time-consuming method to assess the lifespan of yeast cells and to isolate differentially aged cells for microscopic snapshots via manual dissection of… CONTINUE READING
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