Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain

Abstract

Forkhead transcription factors (FOXOs) alter a diverse array of cellular processes including the cell cycle, oxidative stress resistance, and aging. Insulin/Akt activation directs phosphorylation and cytoplasmic sequestration of FOXO away from its target genes and serves as an endpoint of a complex signaling network. Using a human genome small interfering… (More)
DOI: 10.1091/mbc.E10-10-0854

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