Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

@article{Fujimoto2012WholegenomeSO,
  title={Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators},
  author={Akihiro Fujimoto and Yasushi Totoki and Tetsuo Abe and Keith A. Boroevich and F. Hosoda and H{\`a} Thị Hải Nguyễn and Masayuki Aoki and Naoya Hosono and Michiaki Kubo and Fuyuki Miya and Yasuhito Arai and Hiroyuki Takahashi and Takuya Shirakihara and Masao Nagasaki and Tetsuo Shibuya and Kaoru Nakano and Kumiko Watanabe-Makino and Hiroko Tanaka and Hiromi Nakamura and Jun Kusuda and Hidenori Ojima and Kazuaki Shimada and Takuji Okusaka and Masaki Ueno and Yoshinobu Shigekawa and Yoshiiku Kawakami and K. Arihiro and Hideki Ohdan and Kunihito Gotoh and Osamu Yamagata-shi Ishikawa and Shun-ichi Ariizumi and Masakazu Yamamoto and Terumasa Yamada and Kazuaki Chayama and Tomoo Kosuge and Hiroki Yamaue and Naoyuki Kamatani and Satoru Miyano and H. Bardessy N. Nakagama and Yusuke Nakamura and Tatsuhiko Tsunoda and Tatsuhiro Shibata and Hidewaki Nakagawa},
  journal={Nature Genetics},
  year={2012},
  volume={44},
  pages={760-764}
}
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were associated with hepatitis B or C virus infections, including two sets of multicentric tumors. Although no common somatic mutations were identified in the multicentric tumor pairs, their whole-genome substitution patterns were similar, suggesting that these tumors developed from independent mutations, although their shared… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 284 CITATIONS, ESTIMATED 44% COVERAGE

Interplay between the Cancer Genome and Epigenome

VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Next generation sequencing reveals genetic landscape of hepatocellular carcinomas.

  • Cancer letters
  • 2013
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Aberrant chromatin remodeling in gynecological cancer ( Review )

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2012
2019

CITATION STATISTICS

  • 24 Highly Influenced Citations

  • Averaged 25 Citations per year over the last 3 years