Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

@inproceedings{Zhang2013WholegenomeSI,
  title={Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas},
  author={Jinghui Zhang and Gang Wu and Claudia P. Miller and Ruth G Tatevossian and James D. Dalton and Bo Tang and Wilda Orisme and Chandanamali Punchihewa and Matthew Austin Parker and Ibrahim Qaddoumi and Fredrick A. Boop and Charles Lu and Cyriac Kandoth and Li Ding and Ryan Peter Lee and Robert Huether and Xiang Chen and Erin K. Hedlund and Panduka Nagahawatte and Michael C Rusch and Kristy Lynn Boggs and Jinjun Cheng and Jared B Becksfort and Lei Qiao and Guangchun Song and Yongjin Li and Lei Wei and Jianmin Wang and Sheila Shurtleff and John Easton and David Zhao and Robert F Sir Fulton and Lucinda L. Fulton and D. James Dooling and Bhavin K Vadodaria and Heather L. Mulder and Chunlao Tang and Kerri Ochoa and Charles G Mullighan and Amar Gajjar and Richard W. Kriwacki and Denise Sheer and Richard J. Gilbertson and Elaine R. Mardis and Richard K. Wilson and James R. Downing and S. Josephine Baker and D W Ellison},
  booktitle={Nature Genetics},
  year={2013}
}
The most common pediatric brain tumors are low-grade gliomas (LGGs). We used whole-genome sequencing to identify multiple new genetic alterations involving BRAF, RAF1, FGFR1, MYB, MYBL1 and genes with histone-related functions, including H3F3A and ATRX, in 39 LGGs and low-grade glioneuronal tumors (LGGNTs). Only a single non-silent somatic alteration was detected in 24 of 39 (62%) tumors. Intragenic duplications of the portion of FGFR1 encoding the tyrosine kinase domain (TKD) and… CONTINUE READING
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