Whole-genome sequence of Schistosoma haematobium

@article{Young2012WholegenomeSO,
  title={Whole-genome sequence of Schistosoma haematobium},
  author={Neil David Young and Aaron R. Jex and Bo Li and Shiping Liu and Linfeng Yang and Zijun Xiong and Yingrui Li and Cinzia Cantacessi and Ross S Hall and Xun Xu and Fangyuan Chen and Xuan Wu and Adhemar Zerlotini and Guilherme Oliveira and Andreas Hofmann and Guojie Zhang and Xiaodong Fang and Yi Kang and Bronwyn Evelyn Campbell and Alex Loukas and Shoba Ranganathan and David Rollinson and Gabriel Rinaldi and Paul J. Brindley and Huanming Yang and Jun Wang and Jian Wang and Robin B. Gasser},
  journal={Nature Genetics},
  year={2012},
  volume={44},
  pages={221-225}
}
Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release… 
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A study in Nature Genetics has described the sequencing of the whole genome of Schistosoma haematobium for the first time, the blood fluke responsible for causing schistosomiasis and predisposing infected individuals to HIV and AIDS.
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TLDR
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Gene suppression in schistosomes using RNAi.
TLDR
Methods for applying RNAi to suppress gene expression in the intra-mammalian life stages (adults and schistosomula) of Schistosoma mansoni are described.
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New Frontiers in Schistosoma Genomics and Transcriptomics
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Some advances in the schistosome research with emphasis on genomics and transcriptomics are discussed and the main challenges of the current research are discussed to point out some future directions in schistoome studies.
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