Whole-genome sequence of Schistosoma haematobium

  title={Whole-genome sequence of Schistosoma haematobium},
  author={Neil David Young and Aaron R. Jex and Bo Li and Shiping Liu and Linfeng Yang and Zijun Xiong and Yingrui Li and Cinzia Cantacessi and Ross S Hall and Xun Xu and Fangyuan Chen and Xuan Wu and Adhemar Zerlotini and Guilherme Oliveira and Andreas Hofmann and Guojie Zhang and Xiaodong Fang and Yi Kang and Bronwyn Evelyn Campbell and Alex Loukas and Shoba Ranganathan and David Rollinson and Gabriel Rinaldi and Paul J. Brindley and Huanming Yang and Jun Wang and Jian Wang and Robin B. Gasser},
  journal={Nature Genetics},
Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release… 
Infection: Whole genome sequencing of Schistosoma haematobium
A study in Nature Genetics has described the sequencing of the whole genome of Schistosoma haematobium for the first time, the blood fluke responsible for causing schistosomiasis and predisposing infected individuals to HIV and AIDS.
High-quality Schistosoma haematobium genome achieved by single-molecule and long-range sequencing
A substantially enhanced genomic resource that represents a solid foundation for molecular research on S. haematobium and is poised to better underpin population and functional genomic investigations and to accelerate the search for new disease interventions.
Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation
The present reference genome (designated Shae.V3) and the findings from this study solidly underpin future functional genomic and molecular investigations of S. haematobium and accelerate systematic, large-scale population genomics investigations, with a focus on improved and sustained control of urogenital schistosomiasis.
Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo
A lentivirus-based transduction system is used to deliver microRNA-adapted short hairpin RNAs into the parasite to silence and explore selected protein-encoding genes of S. mansoni implicated in the disease process, which has potential to be used for functional genomic–phenomic studies of a range of socioeconomically important pathogens.
Schistosomiasis—from immunopathology to vaccines
Schistosomiasis (bilharzia) is a neglected tropical disease caused by trematode worms of the genus Schistosoma . The transmission cycle involves human (or other mammalian) water contact with surface
New research tools for urogenital schistosomiasis.
Three sets of breakthroughs will accelerate discoveries in the pathogenesis of urogenital schistosomiasis (UGS): comparative genomics, the development of functional genomic tools, and the use of animal models to explore S. haematobium-host interactions.
Gene suppression in schistosomes using RNAi.
Methods for applying RNAi to suppress gene expression in the intra-mammalian life stages (adults and schistosomula) of Schistosoma mansoni are described.
Nuclear genome of Bulinus truncatus, an intermediate host of the carcinogenic human blood fluke Schistosoma haematobium
The genome for a key intermediate host of S. haematobium is defined, protein groups inferred to play a role in its interaction with the schistosome parasite are explored, and expansions in gene families linked to immune response regulation are identified.
New Frontiers in Schistosoma Genomics and Transcriptomics
Some advances in the schistosome research with emphasis on genomics and transcriptomics are discussed and the main challenges of the current research are discussed to point out some future directions in schistoome studies.


The genome of the blood fluke Schistosoma mansoni
Analysis of the 363 megabase nuclear genome of the blood fluke, the first sequenced flatworm, and a representative of the Lophotrochozoa offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and theDevelopment of tissues into organs.
The Schistosoma japonicum genome reveals features of host–parasite interplay
The genome provides a global insight into the molecular architecture and host interaction of this complex metazoan pathogen, revealing that it can exploit host nutrients, neuroendocrine hormones and signalling pathways for growth, development and maturation.
Human schistosomiasis
Genomic linkage map of the human blood fluke Schistosoma mansoni
The genetic linkage map presented here is a first for S. mansoni and the first for a species in the phylum Platyhelminthes, and furnishes a framework for comparative flatworm genomics and field-based molecular epidemiological studies.
Genetic Manipulation of Schistosoma haematobium, the Neglected Schistosome
These findings and approaches should facilitate analysis of gene function in S. haematobium, which in turn could facilitate the characterization of prospective intervention targets for this neglected tropical disease pathogen.
Culture for genetic manipulation of developmental stages of Schistosoma mansoni
Methods to isolate and culture developmental stages of Schistosoma mansoni, including eggs, sporocysts, schistosomules and adults, are reviewed, in particular as these procedures relate to approaches for gene manipulation.
A wake up call for urinary schistosomiasis: reconciling research effort with public health importance
It is argued that greater research effort and focus are needed to improve understanding of this neglected tropical disease, and the inappropriateness of relying solely on data concerning the much more extensively studied intestinal form of schistosomiasis caused by S. haematobium is highlighted.
Helminth Genomics: The Implications for Human Health
Genomes of the major helminth species that affect humans, and many others of agricultural and veterinary significance, are now the subject of intensive genome sequencing and annotation, and the potential impact and importance of these new findings are presented.
A Comparative Chemogenomics Strategy to Predict Potential Drug Targets in the Metazoan Pathogen, Schistosoma mansoni
A comparative chemogenomics approach utilizing the putative proteome of Schistosoma mansoni compared to the proteomes of two model organisms, the nematode, Caenorhabditis elegans and the fruitfly, Drosophila melanogaster generates a tractable set of S. mansoni proteins for experimental validation as drug targets against this insidious human pathogen.
Ascaris suum draft genome
This genome provides a comprehensive resource to the scientific community and underpins the development of new and urgently needed interventions (drugs, vaccines and diagnostic tests) against ascariasis and other nematodiases.