Whole-genome profiling of mutagenesis in Caenorhabditis elegans.

  title={Whole-genome profiling of mutagenesis in Caenorhabditis elegans.},
  author={Stephane Flibotte and Mark L Edgley and Iasha Chaudhry and Jon Taylor and Sarah E. Neil and Aleksandra Rogula and Rick Zapf and Martin Hirst and Yaron S. N. Butterfield and Steven J. M. Jones and Marco A. Marra and Robert J. Barstead and Donald G. Moerman},
  volume={185 2},
Deep sequencing offers an unprecedented view of an organism's genome. We describe the spectrum of mutations induced by three commonly used mutagens: ethyl methanesulfonate (EMS), N-ethyl-N-nitrosourea (ENU), and ultraviolet trimethylpsoralen (UV/TMP) in the nematode Caenorhabditis elegans. Our analysis confirms the strong GC to AT transition bias of EMS. We found that ENU mainly produces A to T and T to A transversions, but also all possible transitions. We found no bias for any specific… CONTINUE READING
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