Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

@article{Fujimoto2016WholegenomeML,
  title={Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer},
  author={Akihiro Fujimoto and Mayuko Furuta and Yasushi Totoki and Tatsuhiko Tsunoda and Mamoru Kato and Yuichi Shiraishi and Hiroko Tanaka and Hiroaki Taniguchi and Yoshiiku Kawakami and Masaki Ueno and Kunihito Gotoh and Shun-ichi Ariizumi and Christopher P Wardell and Shinya Hayami and Toru Nakamura and Hiroshi Aikata and K. Arihiro and Keith A. Boroevich and Tetsuo Abe and Kaoru Nakano and Kazuhiro Maejima and Aya Sasaki-Oku and Ayako Ohsawa and Tetsuo Shibuya and Hiromi Nakamura and Natsuko Hama and F. Hosoda and Yasuhito Arai and Shoko Ohashi and Tomoko Urushidate and Genta Nagae and Shogo Yamamoto and Hiroki R Ueda and Kenji Tatsuno and Hidenori Ojima and Nobuyoshi Hiraoka and Takuji Okusaka and Michiaki Kubo and Shigeru Marubashi and Terumasa Yamada and Satoshi Hirano and Masakazu Yamamoto and Hideki Ohdan and Kazuaki Shimada and Osamu Ishikawa and Hiroki Yamaue and Kazuki Chayama and Satoru Miyano and Hiroyuki Aburatani and Tatsuhiro Shibata and Hidewaki Nakagawa},
  journal={Nature Genetics},
  year={2016},
  volume={48},
  pages={500-509}
}
Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and its underlying etiology and genomic structure are heterogeneous. Here we provide a whole-genome landscape of somatic alterations in 300 liver cancers from Japanese individuals. Our comprehensive analysis identified point mutations, structural variations (STVs), and virus integrations, in noncoding and coding regions. We discovered mutational signatures related to liver carcinogenesis and recurrently… CONTINUE READING
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