Whole-genome landscapes of major melanoma subtypes

  title={Whole-genome landscapes of major melanoma subtypes},
  author={N. K. Hayward and James S Wilmott and Nicola Waddell and Peter A Johansson and Matthew A. Field and Katia Nones and Ann-Marie Patch and Hojabr Kakavand and Ludmil B. Alexandrov and Hazel Burke and Valerie Jakrot and Stephen H. Kazakoff and Oliver Holmes and Conrad Leonard and Radhakrishnan Sabarinathan and Loris Mularoni and Scott L. Wood and Qinying Xu and Nick Waddell and Varsha Tembe and Gulietta M. Pupo and Ricardo De Paoli-Iseppi and Ricardo E. Vilain and Ping Shang and Loretta M. S. Lau and Rebecca A. Dagg and Sarah-Jane Schramm and Antonia L Pritchard and Ken Dutton-Regester and Felicity Newell and Anna Fitzgerald and Catherine A. Shang and Sean M. Grimmond and Hilda A Pickett and Jean Yh Yang and Jonathan Raymond Stretch and Andreas Behren and Richard F. Kefford and Peter Hersey and Georgina V Long and Jonathan Simon Cebon and M. Shackleton and Andrew J Spillane and Robyn P. M. Saw and N{\'u}ria L{\'o}pez-Bigas and John V. Pearson and John F Thompson and Richard A Scolyer and Graham J. Mann},
Melanoma of the skin is a common cancer only in Europeans, whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites) in people throughout the world. Here we report analysis of whole-genome sequences from cutaneous, acral and mucosal subtypes of melanoma. The heavily mutated landscape of coding and non-coding mutations in cutaneous melanoma resolved novel signatures of mutagenesis attributable to ultraviolet radiation. However, acral and mucosal… CONTINUE READING
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