Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma.

@article{Brodtkorb2014WholegenomeIA,
  title={Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma.},
  author={Marianne Brodtkorb and Ole Christian Lingj{\ae}rde and Kanutte Huse and Gunhild Tr{\o}en and Marit E. Hystad and Vera I. Hilden and June H Myklebust and Ellen Leich and Andreas Rosenwald and Jan Delabie and Harald H. Holte and Erlend Smeland},
  journal={Blood},
  year={2014},
  volume={123 7},
  pages={
          1051-4
        }
}
Transformation of follicular lymphoma (FL) to a more aggressive disease is associated with rapid progression and death. Existing molecular markers for transformation are few and their clinical impact is limited. Here, we report on a whole-genome study of DNA copy numbers and gene expression profiles in serial FL biopsies. We identified 698 genes with high correlation between gene expression and copy number, and the molecular network most enriched for these cis-associated genes. This network… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2013
VIEW 1 EXCERPT