Whole-genome discovery of transcription factor binding sites by network-level conservation.

@article{Pritsker2004WholegenomeDO,
  title={Whole-genome discovery of transcription factor binding sites by network-level conservation.},
  author={Moshe Pritsker and Yir-Chung Liu and Michael A. Beer and Saeed Tavazoie},
  journal={Genome research},
  year={2004},
  volume={14 1},
  pages={99-108}
}
Comprehensive identification of DNA cis-regulatory elements is crucial for a predictive understanding of transcriptional network dynamics. Strong evidence suggests that these DNA sequence motifs are highly conserved between related species, reflecting strong selection on the network of regulatory interactions that underlie common cellular behavior. Here, we exploit a systems-level aspect of this conservation-the network-level topology of these interactions-to map transcription factor (TF… CONTINUE READING