Whole-genome association study on tissue tropism phenotypes in group A Streptococcus.

@article{Bessen2011WholegenomeAS,
  title={Whole-genome association study on tissue tropism phenotypes in group A Streptococcus.},
  author={Debra E. Bessen and Nikhil Kumar and Gerod Sharper Hall and David R. Riley and Feng Yu Luo and Sergio Lizano and Candace N Ford and William M. McShan and Scott V. Nguyen and Julie C Dunning Hotopp and Herv{\'e} Tettelin},
  journal={Journal of bacteriology},
  year={2011},
  volume={193 23},
  pages={6651-63}
}
Group A Streptococcus (GAS) has a rich evolutionary history of horizontal transfer among its core genes. Yet, despite extensive genetic mixing, GAS strains have discrete ecological phenotypes. To further our understanding of the molecular basis for ecological phenotypes, comparative genomic hybridization of a set of 97 diverse strains to a GAS pangenome microarray was undertaken, and the association of accessory genes with emm genotypes that define tissue tropisms for infection was determined… CONTINUE READING
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