Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response

@article{Brucklacher2008WholeGA,
  title={Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response},
  author={Robert M. Brucklacher and Kruti M. Patel and Heather D Vanguilder and Georgina V. Bixler and Alistair J. Barber and David A Antonetti and Chengmao Lin and Kathryn F Lanoue and Thomas W. Gardner and Sarah K. Bronson and Willard M. Freeman},
  journal={BMC Medical Genomics},
  year={2008},
  volume={1},
  pages={26 - 26}
}
BackgroundDespite advances in the understanding of diabetic retinopathy, the nature and time course of molecular changes in the retina with diabetes are incompletely described. This study characterized the functional and molecular phenotype of the retina with increasing durations of diabetes.ResultsUsing the streptozotocin-induced rat model of diabetes, levels of retinal permeability, caspase activity, and gene expression were examined after 1 and 3 months of diabetes. Gene expression changes… CONTINUE READING

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