Whole-genome annotation by using evidence integration in functional-linkage networks.

@article{Karaoz2004WholegenomeAB,
  title={Whole-genome annotation by using evidence integration in functional-linkage networks.},
  author={Ulas Karaoz and T. M. Murali and Stan Letovsky and Yu Zheng and Chunming Ding and Charles R. Cantor and Simon Kasif},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 9},
  pages={2888-93}
}
The advent of high-throughput biology has catalyzed a remarkable improvement in our ability to identify new genes. A large fraction of newly discovered genes have an unknown functional role, particularly when they are specific to a particular lineage or organism. These genes, currently labeled "hypothetical," might support important biological cell functions and could potentially serve as targets for medical, diagnostic, or pharmacogenomic studies. An important challenge to the scientific… CONTINUE READING
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