Whole-genome analysis reveals the complex evolutionary dynamics of Kenyan G2P[4] human rotavirus strains.

@article{Ghosh2011WholegenomeAR,
  title={Whole-genome analysis reveals the complex evolutionary dynamics of Kenyan G2P[4] human rotavirus strains.},
  author={Souvik Ghosh and Noriaki Adachi and Zipporah Gatheru and James Nyangao and Dai Yamamoto and Masaho Ishino and Noriko Urushibara and Nobumichi Kobayashi},
  journal={The Journal of general virology},
  year={2011},
  volume={92 Pt 9},
  pages={
          2201-8
        }
}
Although G2P[4] rotaviruses are common causes of acute childhood diarrhoea in Africa, to date there are no reports on whole genomic analysis of African G2P[4] strains. In this study, the nearly complete genome sequences of two Kenyan G2P[4] strains, AK26 and D205, detected in 1982 and 1989, respectively, were analysed. Strain D205 exhibited a DS-1-like genotype constellation, whilst strain AK26 appeared to be an intergenogroup reassortant with a Wa-like NSP2 genotype on the DS-1-like genotype… 

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