Whole-genome analysis of sporadic amyotrophic lateral sclerosis.

@article{Dunckley2007WholegenomeAO,
  title={Whole-genome analysis of sporadic amyotrophic lateral sclerosis.},
  author={Travis L. Dunckley and Matthew J. Huentelman and David W Craig and John V. Pearson and Szabolcs Szelinger and Keta Joshipura and Rebecca F. Halperin and Chelsea Stamper and Kendall Jensen and David Letizia and Sharon E. Hesterlee and Alan Pestronk and Todd D. Levine and Tulio E. Bertorini and Michael C. Graves and Tahseen Mozaffar and Carlayne E. Jackson and Peter Bosch and April Mcvey and Arthur Dick and Richard Barohn and Catherine Lomen-Hoerth and Jeffrey A. Rosenfeld and Daniel T. O'Connor and Kuixing Zhang and Richard C. Crook and Henrik Ryberg and Michael S. Hutton and Jonathan Katz and Ericka P. Simpson and Hiroshi Mitsumoto and Robert Bowser and Robert G. Miller and Stanley H. Appel and Dietrich A. Stephan},
  journal={The New England journal of medicine},
  year={2007},
  volume={357 8},
  pages={
          775-88
        }
}
BACKGROUND Approximately 90% of persons with amyotrophic lateral sclerosis (ALS) have the sporadic form, which may be caused by the interaction of multiple environmental factors and previously unknown genes. METHODS We performed a genomewide association analysis using 766,955 single-nucleotide polymorphisms (SNPs) found in 386 white patients with sporadic ALS and 542 neurologically normal white controls (the discovery series). Associations of SNPs with sporadic ALS were confirmed in two… CONTINUE READING

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