Whole genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing

@inproceedings{Harris2012WholeGA,
  title={Whole genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing},
  author={Simon R. Harris and Ian N Clarke and Helena M. B. Seth-Smith and Anthony W Solomon and Lesley T. Cutcliffe and Peter Marsh and Rachel J. Skilton and Martin J Holland and David C. W. Mabey and Rosanna W Peeling and David A. Lewis and Brian G. Spratt and Magnus Unemo and Kenneth Persson and Carina Bjartling and Robert C. Brunham and Henry J. C. de Vries and Servaas A Morr{\'e} and Arjen G. C. L. Speksnijder and C{\'e}cile Marie B{\'e}bear and Ma{\"i}t{\'e} Clerc and B de Barbeyrac and Julian Parkhill and Nicholas R Thomson},
  booktitle={Nature Genetics},
  year={2012}
}
Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV) biovars from temporally and geographically diverse sources. Our analysis shows that predicting… CONTINUE READING
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