Whole genome analysis of an MDR Beijing/W strain of Mycobacterium tuberculosis with large genomic deletions associated with resistance to isoniazid.

  title={Whole genome analysis of an MDR Beijing/W strain of Mycobacterium tuberculosis with large genomic deletions associated with resistance to isoniazid.},
  author={Qiufen Zhang and Baoshan Wan and Aiping Zhou and Jin-jing Ni and Zhihong Xu and Shuxian Li and Jing Tao and Yufeng Yao},
  volume={582 2},

Genome-Wide Study of Drug Resistant Mycobacterium tuberculosis and Its Intra-Host Evolution during Treatment

It is proposed that the insertion within Rv3785, which was a GWAS hit, might affect cell wall biosynthesis and probably mediates a compensatory mechanism in response to treatment, and shed light on the mechanisms of MTB adaptation to chemotherapy and drug resistance formation.

Severe Clinical Outcomes of Tuberculosis in Kharkiv Region, Ukraine, Are Associated with Beijing Strains of Mycobacterium tuberculosis

Among diverse MTB genotypes discovered in Ukraine, the Beijing genotype (MIRU-VNTR 42425) was significantly associated with risk factors for severe outcomes of disease in the study population, including TB/HIV co-infection and treatment failure.

Characterization of Large Deletion Mutants of Mycobacterium tuberculosis Selected for Isoniazid Resistance

Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant Mycobacterium tuberculosis mutants derived from four M. tuberculosis strains. These LGDs had no growth defect in

Drug resistance mechanisms and novel drug targets for tuberculosis therapy.

Aminophenol-Decorated Gold Nanoparticles for Curing Bacterial Infections.

Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those of conventional antibiotics. This situation may hinder the development of novel



Molecular characterization of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Kazakhstan.

Kazakhstan is one of the 14 countries with a high rate of morbidity due to multidrug-resistant tuberculosis (MDR TB) in WHO European region. The aim of our study was to characterize mutations

Mutations in rpoB gene and rifabutin susceptibility of multidrug-resistant Mycobacterium tuberculosis strains isolated in Australia.

It is concluded that amino acid substitutions at Asp516 and Ser522 in the rpoB gene in RIF-resistant M. tuberculosis predict rifabutin susceptibility for MDRTB.

An Upstream Truncation of the furA-katG Operon Confers High-Level Isoniazid Resistance in a Mycobacterium tuberculosis Clinical Isolate with No Known Resistance-Associated Mutations

To the authors' knowledge, this is the first report showing that deletion of the upstream region preceding the furA-katG operon causes high-level INH resistance in a clinical isolate of M. tuberculosis.

Mutations in gidB Confer Low-Level Streptomycin Resistance in Mycobacterium tuberculosis

The causal role of gidB in conferring a low-level SM-resistant phenotype in M. tuberculosis is demonstrated by evaluating an isogenic ΔgidB mutant strain constructed from strain H37Rv, and the clinical implications of mutations in the gid B gene are examined.

Complete Genome Sequences of Mycobacterium tuberculosis Strains CCDC5079 and CCDC5080, Which Belong to the Beijing Family

Two closely related Beijing family isolates, one resistant to four first-line drugs and one sensitive to them, were completely sequenced and will serve as valuable references for further drug resistance site identification studies and could be of great importance for developing drugs targeting these sites.

Single Nucleotide Polymorphisms in Genes Associated with Isoniazid Resistance in Mycobacterium tuberculosis

A variety of single nucleotide polymorphisms in multiple genes are found exclusively in INH-resistant clinical isolates, and these genes either are involved in mycolic acid biosynthesis or are overexpressed as a response to the buildup or cellular toxicity of INH.

Recent nosocomial transmission and genotypes of multidrug-resistant Mycobacterium tuberculosis.

Investigation of the proportion of tuberculosis cases, including MDR-TB cases, attributable to recent transmission and risk factors associated with clustering found MDR cases were more likely to be found in clusters than drug-susceptible cases.

Role of Large Sequence Polymorphisms (LSPs) in Generating Genomic Diversity among Clinical Isolates of Mycobacterium tuberculosis and the Utility of LSPs in Phylogenetic Analysis

Most LSPs occur in genomic regions that are prone to repeated insertion/deletion events and were responsible for an unexpectedly high degree of genomic variation in clinical M. tuberculosis.