Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris.

@article{Zhang2013WholegenomeDM,
  title={Whole-genome DNA methylation in skin lesions from patients with psoriasis vulgaris.},
  author={Peng Fei Zhang and Mingming Zhao and Gongping Liang and Guangliang Yin and Dan ” Huang and Fengxia Su and Hanyue Zhai and Litao Wang and Yuwen Su and Qian-jin Lu},
  journal={Journal of autoimmunity},
  year={2013},
  volume={41},
  pages={17-24}
}
Psoriasis, a chronic inflammatory skin disorder, is characterized by aberrant keratinocyte proliferation and differentiation in the epidermis. Although the pathogenesis of psoriasis is still incompletely understood, both genetic susceptibilities and environmental triggers are known to act as key players in its development. Several studies have suggested that DNA methylation is involved in the pathogenesis of psoriasis. However, the precise mechanisms underlying the regulation and maintenance of… CONTINUE READING