Whole-exome sequencing reveals novel mutations and epigenetic regulation in hypopharyngeal carcinoma

@article{Wu2017WholeexomeSR,
  title={Whole-exome sequencing reveals novel mutations and epigenetic regulation in hypopharyngeal carcinoma},
  author={P. Wu and H. Wu and Y. Tang and S. Luo and X. Fang and C. Xie and J. He and S. Zhao and Xiaofeng Wang and Jiajia Xu and X. Chen and D. Li and H. Yang and J. Wang},
  journal={Oncotarget},
  year={2017},
  volume={8},
  pages={85326 - 85340}
}
  • P. Wu, H. Wu, +11 authors J. Wang
  • Published 2017
  • Medicine
  • Oncotarget
    • Hypopharyngeal cancer (HPC) frequently presents at an advanced stage, resulting in poor prognosis. Although combined surgical therapy and chemoradiotherapy have improved the survival for patients with HPC over the past 3 decades, the mortality rate in late-stage diagnosis of HPC is unsatisfactory. In this study, we performed whole-exome sequencing (WES) of 23 hypopharyngeal tumor and paired adjacent normal tissue to identify novel candidate driver genes associated with hypopharyngeal carcinoma… CONTINUE READING
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    References

    SHOWING 1-10 OF 25 REFERENCES
    Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1
    • 1,422
    Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck
    • 18
    • PDF
    Downregulation of Calcium-Binding Protein S100A9 Inhibits Hypopharyngeal Cancer Cell Proliferation and Invasion Ability Through Inactivation of NF-κB Signaling.
    • 5
    Multiple region whole-exome sequencing reveals dramatically evolving intratumor genomic heterogeneity in esophageal squamous cell carcinoma
    • 35
    • PDF
    Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas
    • 102
    The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
    • 1,920
    • PDF
    Erratum: Whole genome and transcriptome sequencing of matched primary and peritoneal metastatic gastric carcinoma
    • 26
    • PDF
    Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites
    • 24
    • PDF
    Elevated microRNA-125b levels predict a worse prognosis in HER2-positive breast cancer patients.
    • 29
    Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.
    • 5
    • PDF