Whole-exome sequencing reveals novel mutations and epigenetic regulation in hypopharyngeal carcinoma

  title={Whole-exome sequencing reveals novel mutations and epigenetic regulation in hypopharyngeal carcinoma},
  author={P. Wu and H. Wu and Y. Tang and S. Luo and X. Fang and C. Xie and J. He and S. Zhao and Xiaofeng Wang and Jiajia Xu and X. Chen and D. Li and H. Yang and J. Wang},
  pages={85326 - 85340}
  • P. Wu, H. Wu, +11 authors J. Wang
  • Published 2017
  • Medicine
  • Oncotarget
  • Hypopharyngeal cancer (HPC) frequently presents at an advanced stage, resulting in poor prognosis. Although combined surgical therapy and chemoradiotherapy have improved the survival for patients with HPC over the past 3 decades, the mortality rate in late-stage diagnosis of HPC is unsatisfactory. In this study, we performed whole-exome sequencing (WES) of 23 hypopharyngeal tumor and paired adjacent normal tissue to identify novel candidate driver genes associated with hypopharyngeal carcinoma… CONTINUE READING
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