Whole exome sequencing reveals minimal differences between cell line and whole blood derived DNA.

Abstract

Two common sources of DNA for whole exome sequencing (WES) are whole blood (WB) and immortalized lymphoblastoid cell line (LCL). However, it is possible that LCLs have a substantially higher rate of mutation than WB, causing concern for their use in sequencing studies. We compared results from paired WB and LCL DNA samples for 16 subjects, using LCLs of low… (More)
DOI: 10.1016/j.ygeno.2013.05.005

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Cite this paper

@article{Schafer2013WholeES, title={Whole exome sequencing reveals minimal differences between cell line and whole blood derived DNA.}, author={Chad M. Schafer and Nicholas G. Campbell and Guiqing Cai and Fei Yu and Vladimir Makarov and Seungtai Yoon and Mark J. Daly and Richard A. Gibbs and Gerard D. Schellenberg and Bernie J Devlin and James S. Sutcliffe and Joseph D. Buxbaum and Kathryn Roeder}, journal={Genomics}, year={2013}, volume={102 4}, pages={270-7} }