Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.

@article{Kentsis2015WholeexomeSR,
  title={Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.},
  author={Alex Kentsis and Juliann Chmielecki and Chandra M V Goparaju and Adriana Heguy and Igor Dolgalev and Michele Carbone and Sara Seepo and Matthew L Meyerson and Harvey I. Pass},
  journal={Cancer research},
  year={2015},
  volume={75 2},
  pages={
          264-9
        }
}
Malignant pleural mesothelioma (MPM) is an aggressive neoplasm associated with asbestos exposure. Although previous studies based on candidate gene approaches have identified important common somatic mutations in MPM, these studies have focused on small sets of genes and have provided a limited view of the genetic alterations underlying this disease. Here, we performed whole-exome sequencing on DNA from 22 MPMs and matched blood samples, and identified 517 somatic mutations across 490 mutated… CONTINUE READING
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