Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk.

  title={Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk.},
  author={Kristin A. Rand and Nadin Rohland and Arti Tandon and Alexander Stram and Xin Sheng and Ron Do and Bogdan Pasaniuc and Alexander Allen and Dominique Quinque and Swapan Mallick and Lo{\"i}c Le Marchand and Sam Kaggwa and Alex Lubwama and Daniel O. Stram and Stephen Watya and Brian E. Henderson and David V. Conti and David Reich and Christopher A. Haiman},
  journal={Human molecular genetics},
  volume={25 2},
Prostate cancer is the most common non-skin cancer in males, with a ∼1.5-2-fold higher incidence in African American men when compared with whites. Epidemiologic evidence supports a large heritable contribution to prostate cancer, with over 100 susceptibility loci identified to date that can explain ∼33% of the familial risk. To explore the contribution of both rare and common variation in coding regions to prostate cancer risk, we sequenced the exomes of 2165 prostate cancer cases and 2034… 

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