Whole exome capture in solution with 3 Gbp of data

Abstract

We have developed a solution-based method for targeted DNA capture-sequencing that is directed to the complete human exome. Using this approach allows the discovery of greater than 95% of all expected heterozygous singe base variants, requires as little as 3 Gbp of raw sequence data and constitutes an effective tool for identifying rare coding alleles in… (More)
DOI: 10.1186/gb-2010-11-6-r62

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