Whole-exome Sequencing and an iPSC-Derived Cardiomyocyte Model Provides a Powerful Platform for Gene Discovery in Left Ventricular Hypertrophy

@inproceedings{Zhi2012WholeexomeSA,
  title={Whole-exome Sequencing and an iPSC-Derived Cardiomyocyte Model Provides a Powerful Platform for Gene Discovery in Left Ventricular Hypertrophy},
  author={Degui Zhi and Marguerite R. Irvin and Chloe Chenjie Gu and Alexander J Stoddard and Rachel B Lorier and Anja Matter and D. Chandrasekhra Rao and Vinodh Srinivasasainagendra and Hemant K. Tiwari and Amy Turner and Uli Broeckel and Donna K Arnett},
  booktitle={Front. Gene.},
  year={2012}
}
RATIONALE Left ventricular hypertrophy (LVH) is a heritable predictor of cardiovascular disease, particularly in blacks. OBJECTIVE Determine the feasibility of combining evidence from two distinct but complementary experimental approaches to identify novel genetic predictors of increased LV mass. METHODS Whole-exome sequencing (WES) was conducted in seven African-American sibling trios ascertained on high average familial LV mass indexed to height (LVMHT) using Illumina HiSeq technology… CONTINUE READING
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