Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis

@article{Zuo2015WholeexomeSA,
  title={Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis},
  author={Xianbo Zuo and Liangdan Sun and Xianyong Yin and Jinping Gao and Yujun Sheng and Jinhua Xu and Jian-Zhong Zhang and Chundi He and Ying Qiu and Guangdong Wen and Hongqing Tian and Xiao-dong Zheng and Sheng-xiu Liu and Wenjun Wang and Weiran Li and Yu-yan Cheng and Longdan Liu and Yan Chang and Zaixing Wang and Zenggang Li and Longnian Li and Jianping Wu and Ling Fang and Changbing Shen and Fusheng Zhou and Bo Liang and Gang Chen and Hui Li and Yong Cui and Aie Xu and Xueqin Yang and Fei Hao and Limin Xu and Xing Fan and Yuzhen Li and Rina Wu and Xiuli Wang and Xiaoming Liu and Min Zheng and Shunpeng Song and Bihua Ji and Hong Fang and Jianbin Yu and Yongxin Sun and Yan Hui and Furen Zhang and Rongya Yang and Sen Yang and Xuejun Zhang},
  journal={Nature Communications},
  year={2015},
  volume={6}
}
Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals. We discover 16 SNPs within 15 new genes/loci associated with psoriasis, including C1orf141, ZNF683, TMC6, AIM2, IL1RL1, CASR, SON, ZFYVE16, MTHFR, CCDC129… 
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