Whole chromosome aneuploidy: big mutations drive adaptation by phenotypic leap.

Abstract

Despite its widespread existence, the adaptive role of aneuploidy (the abnormal state of having an unequal number of different chromosomes) has been a subject of debate. Cellular aneuploidy has been associated with enhanced resistance to stress, whereas on the organismal level it is detrimental to multicellular species. Certain aneuploid karyotypes are… (More)
DOI: 10.1002/bies.201200069

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