Whole cell strategies based on lux genes for high throughput applications toward new antimicrobials.

@article{Galluzzi2006WholeCS,
  title={Whole cell strategies based on lux genes for high throughput applications toward new antimicrobials.},
  author={Lorenzo Galluzzi and Matti Karp},
  journal={Combinatorial chemistry & high throughput screening},
  year={2006},
  volume={9 7},
  pages={
          501-14
        }
}
The discovery/development of novel drug candidates has witnessed dramatic changes over the last two decades. Old methods to identify lead compounds are not suitable to screen wide libraries generated by combinatorial chemistry techniques. High throughput screening (HTS) has become irreplaceable and hundreds of different approaches have been described. Assays based on purified components are flanked by whole cell-based assays, in which reporter genes are used to monitor, directly or indirectly… CONTINUE READING

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Immobilized light-emitting E. coli cells expressing LUX genes

  • K. Åkerman, J. Kukkonen, M. Karp
  • Whole Cell Strategies Based on lux Genes…
  • 1990
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