Whole-cell potassium currents in single early distal tubule cells.

  title={Whole-cell potassium currents in single early distal tubule cells.},
  author={Malcolm Hunter and Hans Oberleithner and Ruth M. Henderson and Gerhard Giebisch},
  journal={The American journal of physiology},
  volume={255 4 Pt 2},
The apical membrane potassium conductance of amphibian early distal tubules is sensitive to changes in the intracellular pH, with cellular acidification causing a decreased conductance. With the whole-cell patch-clamp technique, we have measured the total potassium conductance of single isolated early distal tubule cells of the frog. With symmetrical potassium gluconate solutions, the whole-cell current was found to be strongly rectifying, with an inward conductance of 12.9 nS (at intracellular… CONTINUE READING
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