Whole cell patch-clamp recordings of rat midbrain dopaminergic neurons isolate a sulphonylurea- and ATP-sensitive component of potassium currents activated by hypoxia.

@article{Guatteo1998WholeCP,
  title={Whole cell patch-clamp recordings of rat midbrain dopaminergic neurons isolate a sulphonylurea- and ATP-sensitive component of potassium currents activated by hypoxia.},
  author={Ezia Guatteo and Mauro Federici and Anna Siniscalchi and Thomas Kn{\"o}pfel and Nicola Biagio Mercuri and Giorgio Bernardi},
  journal={Journal of neurophysiology},
  year={1998},
  volume={79 3},
  pages={1239-45}
}
The effects of brief (2-4 min) hypoxia on presumed dopaminergic "principal" neurons of the rat ventral mesencephalon were investigated by using either intracellular or whole cell patch-clamp recordings in in vitro conditions. Under single-electrode voltage clamp, with sharp microelectrode (Vh -60 mV), a brief hypoxia caused an outward current (hypoOUT) of 110.2 +/- 15.2 (SE) pA (n = 18), which was followed by a posthypoxic outward current (posthypoOUT) of 149.6 +/- 10.6 pA (n = 18). Although… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 22 references

The pharmacology of the ATP-sensitive MOURRE, C

A. H. WESTON
J. Neurophysiol • 1993
View 1 Excerpt
Highly Influenced

9 : 1233 – 1241 , rones

A. OBERHUSER, P. LABARCA
1996

Hypoxic changes in rat locus coeruGRACE, A. A

K. NIEBER, J. SEVCIK, P. ILLES
J Physiol. (Lond.) 486: • 1995
View 1 Excerpt

Two cell types in rat WU, C., LEUNG, C.K.S., AND YUNG, W. Sulphonylureas reverse hypoxia substantia nigra zona compacta distinguished by membrane properties induced

M. G. LACEY, N. B. MERCURI, R. A. NORTH
J. Neurosci • 1995

outward current in rat dorsal vagal neurons in vitro

rosci
J. Physiol. (Lond.) • 1994

, AND LAZDUNSKI , M . K - channels

G. EDWARDS, Y. BEN ARI, H. BERNARDI, M. FOSSET
Annu . Rev . Pharmacol . Toxicol . • 1993

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