Whole cell patch clamp recording performed on a planar glass chip.

@article{Fertig2002WholeCP,
  title={Whole cell patch clamp recording performed on a planar glass chip.},
  author={Niels Fertig and Robert H. Blick and Jan C. Behrends},
  journal={Biophysical journal},
  year={2002},
  volume={82 6},
  pages={3056-62}
}
The state of the art technology for the study of ion channels is the patch clamp technique. Ion channels mediate electrical current flow, have crucial roles in cellular physiology, and are important drug targets. The most popular (whole cell) variant of the technique detects the ensemble current over the entire cell membrane. Patch clamping is still a laborious process, requiring a skilled experimenter to micromanipulate a glass pipette under a microscope to record from one cell at a time. Here… CONTINUE READING

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