Whole cell patch clamp recording performed on a planar glass chip.

  title={Whole cell patch clamp recording performed on a planar glass chip.},
  author={Niels Fertig and Robert H. Blick and Jan C. Behrends},
  journal={Biophysical journal},
  volume={82 6},
The state of the art technology for the study of ion channels is the patch clamp technique. Ion channels mediate electrical current flow, have crucial roles in cellular physiology, and are important drug targets. The most popular (whole cell) variant of the technique detects the ensemble current over the entire cell membrane. Patch clamping is still a laborious process, requiring a skilled experimenter to micromanipulate a glass pipette under a microscope to record from one cell at a time. Here… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 97 extracted citations

Dynamic ion channel activation scheduling in patch clamp on a chip

IEEE Transactions on NanoBioscience • 2004
View 3 Excerpts
Highly Influenced

The Surfaceome

Methods in Molecular Biology • 2018

Optical electrophysiology: Femtosecond laser facilitated electrophysiological measurements from single cells

2017 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) • 2017

Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans

Journal of Venomous Animals and Toxins including Tropical Diseases • 2017
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 39 references

Neurotransmitter Synthesis by Neuroblastoma Clones

TAKEHIKO XhIANO, Elliott Richelson
View 8 Excerpts
Highly Influenced

Damage induced by high electronic stopping power in SiO2 quartz

M. Toulemonde
Nucl. Inst. Meth. Phys. Res. B46:64–68. • 1990
View 2 Excerpts
Highly Influenced

Ion-channel assay technologies: quo vadis?

Drug discovery today • 2001
View 2 Excerpts

Microstructured glass chip for ion-channel electrophysiology.

Physical review. E, Statistical, nonlinear, and soft matter physics • 2001
View 2 Excerpts

Similar Papers

Loading similar papers…