Whole-cell and single channel monovalent cation currents through the novel rabbit epithelial Ca2+ channel ECaC.

@article{Nilius2000WholecellAS,
  title={Whole-cell and single channel monovalent cation currents through the novel rabbit epithelial Ca2+ channel ECaC.},
  author={Bernd Nilius and Rudi Vennekens and Jean Prenen and Joost G. J. Hoenderop and Ren{\'e} J M Bindels and Guy Droogmans},
  journal={The Journal of physiology},
  year={2000},
  volume={527 Pt 2},
  pages={239-48}
}
This study describes properties of monovalent cation currents through ECaC, a recently cloned epithelial Ca2+-permeable channel from rabbit. The kinetics of currents through ECaC was strongly modulated by divalent cations. Currents were inhibited in the presence of extracellular Ca2+. They showed an initial voltage-dependent decay in the presence of mM Mg2+ at hyperpolarizing steps in Ca2+-free solutions, which represents a voltage-dependent Mg2+ block through binding of Mg2+ to a site… CONTINUE READING