Whole-brain functional imaging at cellular resolution using light-sheet microscopy

@article{Ahrens2013WholebrainFI,
  title={Whole-brain functional imaging at cellular resolution using light-sheet microscopy},
  author={Misha B Ahrens and Michael B. Orger and Drew N Robson and Jennifer M Li and Philipp J. Keller},
  journal={Nature Methods},
  year={2013},
  volume={10},
  pages={413-420}
}
Brain function relies on communication between large populations of neurons across multiple brain areas, a full understanding of which would require knowledge of the time-varying activity of all neurons in the central nervous system. Here we use light-sheet microscopy to record activity, reported through the genetically encoded calcium indicator GCaMP5G, from the entire volume of the brain of the larval zebrafish in vivo at 0.8 Hz, capturing more than 80% of all neurons at single-cell… CONTINUE READING
Highly Influential
This paper has highly influenced 24 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 347 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 12 references

Corrigendum: Whole-brain functional imaging at cellular resolution using light-sheet microscopy

  • Michael B. Orger, Drew N. Robson, Jennifer M. Li
  • 2013

A new look at state - space models for neural data

  • L. Paninski
  • J . Comput . Neurosci .
  • 2010

Similar Papers

Loading similar papers…