Whole-brain and regional brain atrophy in amyotrophic lateral sclerosis.


BACKGROUND AND PURPOSE Recent evidence from neuropsychologic and neuroimaging studies suggests that central nervous system involvement in amyotrophic lateral sclerosis (ALS) extends beyond motor neurons. Our purpose was to obtain measures of global and regional atrophy in nondemented patients with ALS to assess subtle structural brain changes. METHODS MR… (More)


4 Figures and Tables