Whole-body protein turnover from leucine kinetics and the response to nutrition in human immunodeficiency virus infection.

@article{Macallan1995WholebodyPT,
  title={Whole-body protein turnover from leucine kinetics and the response to nutrition in human immunodeficiency virus infection.},
  author={Derek C. Macallan and Margaret A. McNurlan and Eric Milne and A. Graham Calder and Peter J. Garlick and George E. Griffin},
  journal={The American journal of clinical nutrition},
  year={1995},
  volume={61 4},
  pages={818-26}
}
Whole-body protein metabolism was investigated in human immunodeficiency virus (HIV) infection by primed constant infusion of L-[1-13C]leucine in 8 control and 22 HIV-infected subjects (8 stage II; 14 stage IV disease), in postabsorptive and fed states. Postabsorptive leucine flux was increased 25% in subjects with stage IV HiV infection vs that in control subjects (130 +/- 13 vs 103 +/- 10 mumol leucine.kg-1.h-1, P < 0.001); both leucine disposal by protein synthesis (111.6 +/- 12.1 vs 82.3… CONTINUE READING