Whole-body physiologically based pharmacokinetic models.

  title={Whole-body physiologically based pharmacokinetic models.},
  author={Ivan Nestorov},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={3 2},
  • Ivan Nestorov
  • Published 2007 in Expert opinion on drug metabolism & toxicology
This review summarizes the most recent developments in and applications of physiologically based pharmacokinetic (PBPK) modeling methodology originating from both the pharmaceutical and environmental toxicology areas. It focuses on works published in the last 5 years, although older seminal papers have also been referenced. After a brief introduction to the field and several essential definitions, the main body of the text is structured to follow the major steps of a typical PBPK modeling… CONTINUE READING

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